I have used both, (plus a 6mm/284) and I would say 25-06. Now, the 240W is certainly a 'cutie" and a wicked killer too. I have a church member who uses two rifles for the past 40+ years; a Mark V 240W and a 70's model 1895 (straight stock) Marlin 45-70 (saddle gun). He uses nothing but the Nosler 95 partition and the Hornady 350RN in each, respectively. He and one of his sons have killed many mule deer and elk, some of those elk were really big bulls! He has killed more with the 240w than the 45-70. He also killed a humongous mule deer buck (5x5) at almost 500yds a couple years ago. Myself, I feel the 25-06 is more versatile. I also used the 257W and while it is a great round, I feel the 25-06 is just as good.