The one thing that has changed for me when hunting with a sub-moa rifle is, unless I felt the shot was bad (a little too far back, etc.) I feel a lot more confident about where I'll find entrance/exit holes.

I drastically improved the accuracy of my Model 94 Winchester with peep sights, but it's still an open sighted .30-30 lever action carbine, so like you mentioned, I'll limit where I hunt with it.

I love to hunt with it and my Guide gun, which I just (re)install the peeps on and zeroed. Gonna hunt the thick stuff...