Although I love H 380.... I'll admit to using "something else' in the 22.250...

a lot of different powders, but I backed off on H 380 as I noticed a change in performance when I was using it up
in the Cascades at a lower temp when going after coyotes...

For 53 grains and down, I use RL 7...

for 53 grains and up, I use any of the following... 4064, 4895 ( IMR), 3031, Rl 15...

"Minus the killings, Washington has one of the lowest crime rates in the Country" Marion Barry, Mayor of Wash DC

“Owning guns is not a right. If it were a right, it would be in the Constitution.” ~Alexandria Ocasio Cortez