H380 is the only powder I've ever blown a primer with over hundreds of thousands of rounds. It was the old classic 38.0 gr. load behind a 55 gr. ballistic tip which is 3 grains under max from the hodgdon website. It might be a classic but the stuff is pretty temp sensitive and one day when I had heated a rifle up pretty good in the prairie dog town it popped one. No harm done and I didn't notice it until I opened the bolt, but I decided to find something a bit less temp sensitive after that. I settled on AR-Comp and have been using it by the keg since. If H380 was all that was available I'd use it, but there's newer & better stuff out there now.