Kenneth: What is "JR" going to be doing, going after, with his heavy barrel Remington 22-250?
I have a BUNCH of 22-250's most all of them with heavy long barrels and most of them are Remingtons.
I have loads worked up (for accuracy!) for all manner of Varmints and predators.
Let me know if you get specifics.
I will forward this favorite load/Rifle data for now:

Remington XR-100 26" factory barrel
Leupold 8.5x25 variable scope
Varget powder
52 grain Berger MEF bullets
Federal 210M (Match) primers
Winchester brass

On a calm day this load/Rifle will group (5 shots at 100 yards) in the high two's and low threes (.275" to .325")!
I use this load/Rifle for Rock Chucks and Prairie Dogs.
Hold into the wind
VarmintGuy