In my Remington M 7 Predator, 1-14 twist, I am currently only using one load.....a 40 grain Nosler BT and 39.5 grains of Varget. Shoots like a laser out past 300 yards, and kills the snot out of a coyote. If I ever quit using that one, I'll go back to a 52 Speer HP and either H380 or W760 powder........................and large rifle primers.