If you have large temperature swings between the seasons of the year you'll be shooting, H380 and some others like H414 can have large pressure spikes between cooler and hotter weather. A load that is fine at 30 degrees can be way over pressure at 90+.
Easy to cure. I developed my load for the temps it was going to be shot in for both a 22.250 and a Swift. Any powder where the load is at max and the temps hit 90+ you have the potential to go into the danger zone.
