There are so many good combinations for the 22-250 to choose from. I don't care for H-380. It's dirty and pressure peaks quickly. In my first 22-250, way back around 1985, I shot 63 grain Sierras over IMR 4895, and accuracy load from an ancient Lyman loading manual.
That was a Remington 700 Varmint model with a long throat. My next 22-250 was a Cooper. In that rifle I started out with IMR 4895, then switched over to Varget as it is less temperature sensitive. I prefer a 50 grain bullet to a 55 grain bullet, but that's me. If I still had a 22-250, I would probably try CFE 223.
