I’ve only had a couple of 22-250s. My Savage BVSS liked 4064 and 52 MEFs, shot in the .2s if I did my part. My LVSF is crazy picky and likes Varget and about any 40g. I think it took me 5 years before I finally tried the 40s. I was ready to throw in the towel and give up, never shooting better than 3/4” groups. Pretty sure I have almost every single bullet and powder suitable for the caliber and twist rates 😂.