Personally if I wanted to use lighter then 300gr. bullets in a 375 caliber I would of went with 35 caliber or 338 caliber. I load Nosler 300gr. Accubond and Woodleigh 350gr. PP bullets in my Ruger 375 Guide Gun. I have killed deer and elk with the Nosler 300gr. Accubond bullets and very happy with results. With Nosler 300gr. Accubond bullets chronographed at 2590fps average velocites in my 20" barrel. Woodleigh 350gr. PP bullets are 2391fps average. I haven't shot any game with the 350gr. bullets yet. But I don't need anymore velocity in shooting in the 375 caliber. I get less blood shot and wasted meat with the heavier lower velocity bullets. Like a sledge hammer compared to a ball peen hammer. Just my 2 cents worth.

Nothing like a Remington 700xcr.