I've never had anything but good luck with the 243. I use it or something similar (243 AI, 6CM) for most of my deer hunting. 0 to 400 yards, mixed timber or pasture/edges.

I've had good luck with any of the 100 grain cup and core bullets but the hornady is my pick. Also lots of 105 hpbt hornadys and 95 ballistic tips. The last 2 seasons I've used the 90 grain Sierra gamechanger and like it a lot