It could happen at any time. Buddy built a 6.5-06 years ago and proceeded to put the smack down on a good size doe about 50 yards away with a SGK, believe it was a 140 grains. Doe ran off and we found her piled up about 50 yards away, when we skinned her, there was a hole in her ribs about 4" in diameter. If I didn't look for that deer with him, I would have said that died on the spot...it just sometimes happens