Once upon a time, in a far away place, I used a 243 on Midwest whitetails. Never lost one but when I killed the largest bodied buck I had ever seen with a neck shot, using old round nose Texan 100 gr bullets, and discovered the old cup and core, non-bonded bullet had been stopped and destroyed by the neck bones, I deduced that the 243 was maybe marginal for large deer and moved up to the 270. Now, half a century later and having killed a lot more deer ( and a few other larger animals) with numerous other bullets and calibers I have concluded the 243, with today's excellent Bullets, makes a dandy caliber for whitetail, Blacktail and any other deer. In fact I have a new, old Husqvarna .243 I plan on keeping in hunting camp for use on our subsistence deer and caribou hunts. With Partitions and TSX bullets.