Ruger LCR 22 is the only choice she will be comfortable with that will work correctly in a gunfight for someone who knows nothing about guns.
Point, pull the trigger. Keep pulling until you're done. Smooth trigger pull, no hammers to snag or bite, no slides to rack, no worry about the lack of reliability in rimfire ammo, no recoil.
Her engagement range literally needs to be 10 feet, or usually much less. She won't miss much at that range.
Use CCI Velocitors.
