Jeff,
Eileen has been using 100-grain TTSX's exclusively in her NULA .257 since they appeared in 2004, but she has used the rifle not only for deer and antelope but elk. No doubt a 120 Partition would also work fine on elk (and she used to use them for deer and antelope, along with the 115 Ballistic Tip), but sticking with one load also has virtues.
However, she also knows monos sometimes don't drop animals as quickly as lead-cores, and in fact her biggest mule deer buck of the past several years went around 100 yards after taking one right behind the shoulder. But that was in wide-open sagebrush country. If she wants them to drop right there, she doesn't hesitate to use the spine-shoulder shot.
