Up here in the high plains of ND, the .22-250 REM is my king.
I have 3 of them that get regular workouts on coyotes. A Model 70 Coyote, Model 70 Sporter, and Model 70 Lightweight.
50 gr. V-Max over Varget @ 3835fps (24" bbl) is big medicine. I have .17, .222, .223 and .243 's in my arsenal. But when I get serious on coyotes, it's the .22-250 hands down.

WB