Friends have taken a couple with the 243. I've taken a decent number with a 270, both with 130 and 150 grain bullets, even core-lokts. I know a 270 can put them down quick. I haven't taken one with a 6.5. I have no doubt they would work fine. If I have the option I'd prefer at least a 270 but a 243 can get it done. Put a decent bullet in the right place with most any common cartridge and it will do the job. Grizzlies have become much more common in elk country and if I have an unpleasant encounter with one, I'd prefer something bigger than a 243. Whatever I have on hand I'd prefer to have a good bullet for that situation.
