I shoot a 300 WSM which is very close to the 300 WM. I'd never try a 450 yd shot but I have shot a couple elk at about 300. A 30-06 will normally do just fine at that range. I was actually after a 30-06 when I bought it but it only came with a front sight while the 300 came with a clean barrel.

“In a time of deceit telling the truth is a revolutionary act.”
― George Orwell

It's not over when you lose. It's over when you quit.