Roper,
A 280AI chambering a 180 Berger VLD would be a special deal. With the bullet ogive of the 180 Berger and trying to chamber a rifle to seat that thing just right in the neck would make it a little different but that would be one bad piece if a guy could get that 180 out the muzzle about 3000 fps. 26" tube and lots of something pretty slow might get it done.
The NULA I shoot in 280AI seems to be pretty accurate. It likes N165 (thanks Tim in TN) and IMR 4831 awful well. I've been messing with some 120 TTSX's but cannot seem to get them up to speed and nearly as accurate as a 140 in almost any flavor. Not sure but I think the barrel on mine is a 1 in 10. Need to confirm that.
62.9g of N165 or 60g of IMR 4831 behind any 140 is around 3140 and shoots real well especially for such a light rifle. What does yours like??

Dave