50 V-Max from a 22-250 will disassemble a jack pretty quick. We popped about 5 of them on our last PD shoot just cause there were so many of them.
It doesn't take a .22/250, a .221 Fireball with 50VMaxes work just as well . I had one come right up to me to investigate what I was doing (eating lunch at the pickup), so I reached over and got the little CZ and chopped him up).
Over all, that's my favorite .224" bullet, bar none.
You can roll a turd in peanuts, dip it in chocolate, and it still ain't no damn Baby Ruth.