Possibly. One just needs to learn how one's trajectory matches up with the reticle. There are several fellows on here who are quite adept at using a regular old duplex out to quite a bit over 350 yards. I think my furthest kill with a standard duplex was on a previously wounded (by another fellow) pronghorn at just over 400 yards with a Leupold 8x on a 223. I had been shooting prairie dogs all summer with the rifle, and knew the trajectory like the back of my willie.