Here we go again using energy as the deciding factor for killing a deer. While the 357 will work (I've done it) its really on the minimum side for deer, but again it will work. Moving up to the big three, 41, 44 & 45 they are easily able to take deer with quality hits & will almost always exit if using good ammo. Don't look for the "knock down" effect of riles, you won't usually see it, but the sixgun is deadly in the hands of good shooters. You need placement & penetration & you can punch your tag! If you need more horsepowder you can move up to the 454, 460 or the mighty 500, along with additional recoil. Shoot what you can handle & the sixgun is a great hunting weapon.

Dick