Well I've used the .50 295 with 150gr Pyrodex pellets and non have failed. One buck was facing me straight on and shot him in the chest at 60yds. The PB traveled length wise and ended lodged in his rear hind leg. Bullet weighed 270 gr and mushroomed perfectly. The shot sat him on his rear and almost flipped him over. The rest have all been pass throughs with sledge hammer like effect on deer.
