My 45-70 and its 405 grain cup n core will likely end to end a deer or elk. Not something I would consciously do though.
This type of discussion is akin to my need of a Ford 350 crew cab long bed diesel pickup to get to the office.
I use a 436 grain LBT....for deer....
I tend to use slightly heavy cup-n-core bullets in non-magnum rifles, the .308 being my most-often used cartridge.