Go as light as they make and fling them like a varmint load then.
For deer sized stuff going to smaller calibers at higher velocities gives one pause towards "overbulleting".
People were debating similar things 100 years ago; the old ways worked, but so did the new ones, with some advantages.
I guess it isnt as much for the OP as it is for the modern day cup and core, traditional deer cartridge fan.
