A medium/heavy for caliber cup-core kept at 2,800fps or less seems to generally perform close to perfectly, at least in my experience, when shooting hogs and deer. Ones that come to mind are the 168gr .30cal NBT and the 160gr 7mm NAB. They still dig pretty deep but disrupt a fair bit of tissue along the way. I'd also not be afraid of plain old Interlocks in those calibers/weights. But overall, it is indeed true that no bullet is the perfect choice all the time. A really good choice most of the time is about the best you can hope for.
