I am a believer in what Mule Deer says about the Barnes. With small caliber TSX's there is a risk that they won't open (<.30) because of the small hollow point. TTSX's have a bigger hollow point and the plastic tip helps get things started. I quit using TSX's in my small bores. I have a .350 Rem Mag that I use for bear with 200 gr TSX's because of mag constraints. It has a very large hollow point. I have only caught one and it had text book expansion. Penetration was fantastic.
When it comes to deer hunting, I always aim for the shoulder regardless of what bullet I am shooting. They are easy to drop on the spot.