My first African trip in 2010 was plains game only and I took my trusty .338 Win Mag. It did it all with very little fuss.
When I re upped in 2015 and wanted to include cape buffalo, I first bought a CZ in 458 Lott. It shot 500 gr pills and was a little snappy from the bench.
I settled on a Dakota M76 in 416 Rigby, which shot 400 gr bullets very well, and I took my 338 Win Mag for everything else. That was my ticket to success.
donsm70