I had a dear friend ( deceased now) who went to Zimbabwe a few years back with a stock Mod 70 Express in .375, but with 300 TSX handloads. He shot elephant, some antelope and a leopard with it, easy cheesy. I do think the Barnes 300 TSX is the way to go for buffalo in the .375. I used a standard Mod 700 BDL SS in .375 H&H ( 90's) for elk hunting in the mountains. It was just light enough to be fun to hunt with but just heavy enough to "push well". I used the Sierra 300 sbt in it. I gave it to a young man who went to SA with us in 2002. He used the factory 270 Failsafe ammo for zebra, black wildebeest, impala, wart hog, blesbuck, waterbuck and hartebeest. I liked the monos best of all in everything we shot.