If you're interested in a rifle for Cape Buffalo, and not an "all around' African caliber, I'd move up to a 416 or 458. A 375 will kill a Buffalo, for sure, but they can be VERY tenacious of life. I'd rather hunt Elephant (brain shot) with a 375 than Cape Buffalo. I've been to Africa 16 times, so I'm not a newbie when it comes to Buff hunting.
