I've only seen one Cape Buffalo Bull up close ( 75yds as we drove by it) on a big farm south of Joberg. They had some Rhino on the place too, saw them up so close, one of them swiped the front bumper of the Toyota PU ( bakkie) Anyhow, that one bull reminded me of looking at a Limousine Bull at the Houston Livestock show, ha. Big...really big. While I would use a 375 if that was all I could handle, I myself would feel better with a 458 Lott! Or at minimum a 404 Jeffry with 400gr. I don't think I would enjoy shooting a .510 Wells, but I would try it if I had access to one, ha. But I feel the same way about those big humped back bears! smile