A large antelope buck might go 120lbs. They are easily taken with 24,25,& 6.5 light weight bullets. A rib cage shot is highly recommend. A hit thru the shoulder or ham can be very destructive to their fragile skeletal frame. . Any 6.5 will handle antelope to elk with the right bullet. You won't go wrong with a 6.5 as it gives you the versatility of much heavier game. Any 6.5 bullet from 85 to say 130 gr will give a flat trajectory over realistic ranges. And for sure mild recoil.