I love to hunt with old fashioned guns and mostly with iron sights. But if the guns were to be judged on the ballistic merits of their power range, accuracy and the trajectory that most closely matched the ability to make hunting easier, the 2 I would choose are:

#1 My 270 Winchester for open ground hunting of deer elk and antelope. (I seldom do this on the 1st one because it makes the hunts too easy and fast. With my 270 hits to 550 yards are quite easy, and getting inside of 550 yards is very very easy )

#2 My 9.3X62 or my 375H&H for brush and timber hunting where we have a lot of elk, some moose and a lot of grizzlies. (I do use these rifles quite a lot because they are both classic Mausers and I like them a lot, but also because the number of Grizzles make me feel a bit better in heavy brush when I have a "bigger club" in my hands to hit with)