In FL and SC, I have taken more deer the past 10 years with a 7mm-08. These states are my "region".
25-06 has taken a few and I like it too but is a Ruger #1 Stainless and it just doesn't get used as much as the 7mm-08s.
Also taken a few with 7mm Rem Mag (trophy rifle for paid hunts), 6.8SPC bolt gun (pleasure to shoot), various 22 centerfires in bolt and AR platforms, and a 257 WBY Accumark.
I had a 280 AI built on a Ti action that I thought would be my main go-to but the 7mm-08 just keeps performing too well, shoots like a dream, and is pleasant on the shoulder in both recoil and long walks.
