Never had one come loose, so never felt the need, until I bought a .22 Match barrel for my G2 Contender. The screw holes were shallow, forcing me to shorten the screws of my EGW rail. Probably would never cause trouble on the rimfire, but just to be safe I mixed up some clear epoxy and ran a bead on the rail, staying clear of the holes. When I torqued it down, the glue oozed out a bit and I wiped it flush. I can see it on the edges, so if it ever lets go, I should be able to see that. I think the loctite on the screws should've kept the glue out of those holes.
The instructions for the Burris bases I put on my Alpine said to smear loctite on the bottoms, so I did. We'll see how that works out.
