2 things. The OP never ask about using epoxy on the screws. He ask about using epoxy on the bases. I always do. The other thing is about JB Weld being :"weak" epoxy, JB Weld is rated at the top for strength in 2 part epoxies.

If you don't jig align and epoxy bed 2 piece bases, they are most likely out of alignment. More so on some guns/bases than others. RJ