I'm getting too old for a grizzly hunt, I suppose. I think though I'd be carrying my 375 Whelen AI on a Mauser 98 action if I were to go. I sold my last 338. I might (probably not) take my pre-64 375 H&H AI.
But I recall the killing of the polar bear with a 22 LR was by a native gal - Eskimo if you will, not an interior grizzly bear.
This is a link to the actual story about the World Record grizzly bear being shot by an elderly Native woman, with a 22lr.