" No. 1 300H&H and 180g Interlocks" - seem like a very good choice to me. And shoot that one shot in the right "spot"

But your scope is likely more important than your rifle or cartridge. Most leopards are hunted in poor light from a stable shooting position. The others, well then you need instinctive quick handling and reliability and power...
I'd probably choose my 9.3x74R O/U double Beretta Express, with S&B 1.5-8x42 Stratos scope with illuminated reticle. I'd load it with a 286 gr. round nose bullet with lots of lead exposed, like the Norma Alaskan. It's accurate and deadly on the first shot, in any light and from any position, and quick and deadly if a second shot is needed.

Last edited by castnblast; 03/26/21.