A good sized Tom leopard is about the size of man. If you look at the thoracic anatomy of both when on all fours, the heart and lungs lies in a similar position. Unlike ungulates that stuff the heart and lungs between the shoulder blades due to bug stomachs, the heart- lungs tend to be a bit posterior to a line that runs between the center of the shoulders.
I use 9.3 x 62 with my last remaining stash of RWS 256 H-Mantles They act like Nosler Partitions so big hole as it enters and will punch through any angle. Leopards being man sized, plucking on from a tree with a .243 I'm sure would do the the deed, but make many PH's nervous to have their clients use that. Honestly, I've advise 7mm on up, with 30-06 or .300 mag being easy to shoot and effective. I like bigger, so I use bigger.
