My philosophy has always been to carry a rifle capable of dealing with unexpected situations. I've only carried two rifles in Africa : "light rifle" - 375 H&H, Heavy Rifle - 458 Lott.
For a leopard hunt, a 375 H&H would be my pick. Ammo in camp is likely to be found if needed and the 375 H&H is adequate for bigger stuff if circumstances present themselves. While the 375 H&H is very effective, it does not cause extreme collateral tissue damage and recoil is not uncomfortable.
T.S.
