I'll never have the opportunity, but I'd think the ideal leopard rifle would be a relatively fast medium bore throwing a fairly frangible pill. To that end, I'd go .325 WSM. I shot a buck last season with a 180gr Ballistic Tip in the .325 and have never seen such a blood trail in my life, looked like a crime scene. The 8mm Ballistic Tip, or possibly a Hawk 180 or 200gr soft round nose would blow kitty clockwork all over the tree he was perched in.