I've shot at least one deer with each of the different cartridges that Savage chambered the 1899/99 for except the 22HP, 7mm08, 303 SAV, 32-40, and 38-55. I've also shot at least one deer with 99s chambered for 6 non-cataloged or wildcat cartridges; 6-284, 25-284, 257AI, 260, 6.5-284, and 40-55.

I like the post-WW2 99F for still-hunting, the post-WW2 99R for hunting from a stand, and the 99C/CD for wildcatting. The 99F in 243 that I had rebored/rechambered to 260 is, IMO, close to a perfect match of rifle and cartridge for hunting medium game.