In the morning a lung shot is prefered as you have all day to deal with it. In the evening a shoulder shot will anchor them most of the time. I shot moose for 10+ yrs with a 7mag and rarely did I get one shot knock down, switched to a 35Whelen and one shot knock downs became expected as any good medium will do 33 ,35,36 and 37 calibers. Moose do not always stand perpendicular to the shooter so its nice to have enough momentum to get through the paunch to the vitals so he doesn't move away, a medium with bullets between 225gr and 300grs will do that @ => 2500fps. I consider the sub 30 calibers for local experts who can wait for the right moose and the right shot, that's why the 270Win shines in the right hands!