Let me fix that...

243 + right bullet + VITALS Placement = Death wink

Wrong bullet, placement, or both, like any round can = slower death or not, tracking or lost....

But no doubt, the 243 is a killer when used properly, even the pipsqueak 6BR using 28-30 grains of powder will do 90% of a 243 speed, and is deadly, esp. when twisted to use the better bullets.