Shot more than a few deer and antelope with 6mm bullets in the 243 and 6mm 100 gr Horn SP and 100 gr Corelokt work well as does the 100 and 95 gr NPT. Primarily shoot double lung or if the shot is quartering away I aim for the FAR shoulder, where I hunt DRT's aren't as important as they are to some here on the fire. To me the basic key to shoulder shots is to get thru the vitals first and the shoulder on the exit , never ever saw that fail. Magnum man