I am surprised that no one has mentioned the Nosler 95g Partition. The 95g Partition will hammer through both shoulders with ease in a 243 or 6 Remington.

85g Tripple shocks will break shoulders and exit rib cages from quartering angles! I did a Texas heart shot on a doe, 100 yd shot, with a load of 44.5g of R#19, WLR, 85g TXS, she dropped at the shot. The bullet traveled the length of the doe, found it under the hide as it was about to exit after traveling through the front shoulder.

I am a firm believer in shoulder shots...been that way for 30+ years.