Other than you are a one gun man with a bigger caliber, why would you ever feel the need to use anything bigger than a .243 Win for whitetail?
Because you can?
Yup!
you want something that will put em' down, and if not leave a blood trail a blind man could swim upstream in. Not much fun tracking in cactus, catclaw and junipier thickets after dark.
JAPPFT,
GWB