I don't think it matters too much for deer, at least the monsters I shoot off my land in East Texas (sarcasm).
Last 2 deer I've taken off my property were with a 257R with 120 Interlock at 2700 fps and a 6.8 SPC with 115 Fusion at 2450 FPS.
Both were bang flop.
Last hunt I went on where I had to fork out hard earned dollars for a free range Axis hunt, I went a little bigger with a 338 Federal, mainly because is shot so well with 180 Ballistic Tips and I wasn't sure how far I'd be shooting.
Those Ballistic Tips were bought from SPS for 20 cents a bullet which could open another argument of using cheap bullets for an expensive hunt.
