Other than you are a one gun man with a bigger caliber, why would you ever feel the need to use anything bigger than a .243 Win for whitetail?
Seriously.... because there are better cartridges & calibers for hunting WTs under ANY/ALL conditions.
That said, I've had 243s and still have a 6mm R and killed deer with all of them. I've had bang flops and bang-run offs and LONG difficult tracking jobs because of little/no blood trail.
