I have to draw the line at 416 for heavy dangerous game. That is as big a cartridge I can shoot comfortably and accurately. After having shot a bunch of 375 H&H, 416 Rigby, 404 Jeffery (2nd favorite), 458 Winchester and Lott.
I have stated this before, I would comfortably take one of my 338-06's for anything huntable, with the exception of elephant or rhino. I do not see the extra 200 fps of the RPM as a huge advantage.
